HELPING THE OTHERS REALIZE THE ADVANTAGES OF PKRRATING

) mechanism16,thirty–34 [for just a contrary look at see35]. The BTB dimer orients the Energetic internet sites far from the dimer interface in a configuration that cannot mediate this reaction. in this article, we report buildings of wild-type, unphosphorylated PKR kinase. The kinase domains interact by using the BTB interface and adopt an Livel